Publication

Updates
 

• Young researchers in lab: Observership in Epilepsy Lab at Acibadem University
• GEMSTONE presents special video series honoring Prof. Ray Guillery
• Call for poster presentations at GEMSTONE's first dissemination event
• Agenda of GEMSTONE's first dissemination event: Regional Symposium on neurodevelopmental disorders and genetically engineered models
• Highlights from GEMSTONE's first dissemination event: Regional Symposium
• GEMSTONE Newsletter 2022-2023 released
• GEMSTONE researchers attend EARMA 2024 Conference
• GEMSTONE dissemination event: Challenges and Developments in Parkinson's and Neurodegenerative Diseases
• GEMSTONE team to join in Graduate Programmes Information Days at ACU
• GEMSTONE's successful attendance at ACU Graduate Programmes Information Days
• GEMSTONE hosts dissemination event on Parkinson's and neurodegenerative diseases
• Dr. Devrim Oz Arslan represents GEMSTONE at FENS Forum 2024
• GEMSTONE to be represented at EMC 2024 in Copenhagen
• Dr. Merve Acikel Elmas represents GEMSTONE at EMC 2024
• GEMSTONE & ACUTBAT Neuroscience Symposium on approach to epilepsy
• GEMSTONE & ACUTBAT Neuroscience Symposium illuminates the path to advancing epilepsy research
• GEMSTONE launches video series showcasing project team members
• ACU Head Librarian to highlight GEMSTONE Project at Health Literacy Summit
• ACU Library and GEMSTONE Project shines at Health Literacy Summit
• GEMSTONE researchers publish new paper on role of glial cells in epilepsy
• Introducing GEMSTONE Newsletter 2024: A year of progress and innovation
• Call for participants: Dissemination event on research capacity building for chemogenetic experiments
• Register now: Programme out and deadline extended for GEMSTONE’s chemogenetic dissemination event
• Prof. Filiz Onat presents GEMSTONE research at Synuclein Meeting 2025 in Cambridge
• GEMSTONE researchers present scientific findings at national epilepsy symposium
• GEMSTONE team joins MD-PhD Programmes Info Day to inspire future neuroscientists
• GEMSTONE dissemination event empowers regional researchers to build capacity in chemogenetics
• GEMSTONE intern Zeynep Kaya shares her experience at ACU in new video interview
• GEMSTONE at EPNS 2025: Prof. Onat presents research on absence epilepsy in Munich
• GEMSTONE engages future students at ACU’s 2025 Open Days
• New publication: GEMSTONE releases “Making It Work” – a guide to better practices for Horizon Europe newcomers
• GEMSTONE team showcases epilepsy research at IEC 2025 in Lisbon
• GEMSTONE team at Building Bridges 2025: Sharing best practices and exploring AI-driven collaboration in Dresden
• ACU and TU join forces to strengthen regional collaboration in Info Day through networking and knowledge sharing
• Join us at ACU NeuroConnect: A celebration of brain science and young minds

• Oğuzhan Altınkoz, Cem Öztürk, Filiz Onat. Making It Work: GEMSTONE Project's Better Practices for Horizon Europe Newcomers. Acıbadem Mehmet Ali Aydınlar University Publications, 2025. doi.org/10.5281/zenodo.16900756.

• Nihan Çarçak Yılmaz, Filiz Onat, Evgenia Sitnikova. "Astrocytes as a Target for Therapeutic Strategies in Epilepsy: Current Insights." Frontiers in Molecular Neuroscience, Vol. 16, 2023. doi.org/10.3389/fnmol.2023.1183775.

• Marco Ledri, My Andersson, Jenny Wickham, Merab Kokaia. "Optogenetics for Controlling Seizure Circuits for Translational Approaches." Neurobiology of Disease, Vol. 184, 2023. doi.org/10.1016/j.nbd.2023.106234.

• Aylin Toplu, Nursima Mutlu, Elif Tuğçe Erdeve, Özge Sarıyıldız, Musa Çelik, Devrim Öz Arslan, Özlem Akman, Zoltán Molnár, Nihan Çarçak Yılmaz, Filiz Onat. "Involvement of Orexin Type-2 Receptors in Genetic Absence Epilepsy Rats." Frontiers in Neurology, Vol. 14, 2023. doi.org/10.3389/fneur.2023.1282494.

• Melis Yavuz, Pelin İyiköşker, Nursima Mutlu, Serra Kılıçparlar, Öykü Hazal Şalcı, Gökçen Dolu, Elif Nur Kaymakçılar, Serdar Akkol, Filiz Onat. "Dexmedetomidine, an Alpha 2A Receptor Agonist, Triggers Seizures Unilaterally in GAERS during the Pre-Epileptic Phase: Does the Onset of Spike-and-Wave Discharges Occur in a Focal Manner?" Frontiers in Neurology, Vol. 14, 2023. doi.org/10.3389/fneur.2023.1231736.

• Melis Yavuz, Serdar Akkol, Filiz Onat. "Alpha‐2a Adrenergic Receptor Activation in Genetic Absence Epilepsy: An Absence Status Model?" Epilepsia Open, Vol. 9, 2024. doi.org/10.1002/epi4.12879.

• Filiz Onat, My Andersson, Nihan Çarçak Yılmaz. "The Role of Glial Cells in the Pathophysiology of Epilepsy." Cells, Vol. 14, 2025. doi.org/10.3390/cells14020094.

• Aylin Toplu, Nursima Mutlu, Elif Tuğçe Erdeve, Özge Sarıyıldız, Nihan Çarçak Yılmaz, Zoltán Molnár, Filiz Onat. "Injection into the Intracerebroventricular or Thalamus, or Cortex: Effects on Absence Epilepsy Seizures." 23-26 November 2023, 27th National & 2nd International Pharmacological Congress, Antalya, Türkiye. tfd.org.tr/images/yayinlar/evraklar/2.Uluslararas%C4%B1-27.Ulusal-Farmakoloji-Kongresi-Bildiri-Kitab%C4%B1.pdf.

• Melis Yavuz. "Absence Status Epilepticus Model and Potential Treatments." 23-26 November 2023, 27th National & 2nd International Pharmacological Congress, Antalya, Türkiye. tfd.org.tr/images/yayinlar/evraklar/2.Uluslararas%C4%B1-27.Ulusal-Farmakoloji-Kongresi-Bildiri-Kitab%C4%B1.pdf.

• Aylin Toplu, Nihan Çarçak Yılmaz, Rezzan Gülhan, Filiz Onat. "Impact of Orexin-B Injection into the Intracerebroventricular Region on Absence Epilepsy Seizures." 3-6 September 2024, 22nd Turkish Neuroscience Congress, Istanbul, Türkiye. usk2024.org/page/kongre-kitabi.

• Elif Tuğçe Erdeve, Filiz Onat, Nihan Çarçak Yılmaz. "Orexin-A Dose Dependently Suppresses Spike-and-Wave Discharges in Genetic Absence Epilepsy Rats: The Role of Orexin Signaling in Absence Seizures." 7-11 September 2024, 15th European Epilepsy Congress, Rome, Italy. doi.org/10.1111/epi.18151.

• Nursima Mutlu, Devrim Öz Arslan, Merve Çavuş, Nihan Çarçak Yılmaz, Filiz Onat. "Investigation of Orexin Type-1 Receptor Protein Levels in the Somatosensory Cortex of Rats with Absence Epilepsy." 16-18 May 2025, 8th Epilepsy Symposium, Muğla, Türkiye. epilepsisempozyumu.org/bildirikitabi.pdf.

• Aylin Toplu, Nihan Çarçak Yılmaz, Rezzan Gülhan, Deniz Kırık, Filiz Onat. "Immunohistochemical Analysis of Orexin-A Expression in the Lateral Hypothalamus in Rats with Absence Epilepsy." 16-18 May 2025, 8th Epilepsy Symposium, Muğla, Türkiye. epilepsisempozyumu.org/bildirikitabi.pdf.

• Samed Özer, Aslı Önder Gül, Meltem Kolgazi, Filiz Onat. "Optimization of Superovulation, Embryo Collection, Embryo Laboratory, Culture Media and In Vitro Development Rate in Animal Experimental Facilities: Preliminary Study." 4-6 September 2025, 6th National Congress on Laboratory Animal Science, Aksaray, Türkiye. labbilim.org.tr/yuklemeler/18%20-%20E-BOOK%20G%C3%9CNCEL-son%20_compressed.pdf.

• Aylin Toplu, Nursima Mutlu, Elif Tuğçe Erdeve, Özge Sarıyıldız, Nihan Çarçak Yılmaz, Zoltán Molnár, Filiz Onat. "Intracerebroventricular or Intraparenchymal Administration of Orexin Type-2 Receptor Agonist on Spike-and-Wave Discharges of Genetic Absence Epilepsy Rats." 2-6 September 2023, 35th International Epilepsy Congress, Dublin, Ireland. ilae.org/9C57AC24-074B-CE92-4E5642CC9E0ADF5D.

• Elif Tuğçe Erdeve, Nursima Mutlu, Özge Sarıyıldız, Nihan Çarçak Yılmaz, Filiz Onat. "The Effect of Intracerebroventricular Orexin-A Injection on Spike-and-Slow-Wave Discharges in Rats with Genetic Absence Epilepsy of Strasburg Origin." 23-26 November 2023, 27th National & 2nd International Pharmacological Congress, Antalya, Türkiye. tfd.org.tr/images/yayinlar/evraklar/2.Uluslararas%C4%B1-27.Ulusal-Farmakoloji-Kongresi-Bildiri-Kitab%C4%B1.pdf.

• Melike Şahiner, Serena Cogoni, Eda Tanoğlu, Filiz Onat. "GEMSTONE: Enhancing Research Support Services." 23-25 April 2024, EARMA Conference, Odense, Denmark. earma.org/abstracts/submission/1076/view/.

• Nursima Mutlu, Merve Açıkel Elmas, Neval Sevinç Özdemir, Nihan Çarçak Yılmaz, Zoltán Molnár, Filiz Onat. "Distribution of Orexin Type-2 Receptor in Cortical Layers of Genetic Absence Epilepsy Rats." 16-19 May 2024, 14th National Epilepsy Congress, Muğla, Türkiye. turkepilepsi.org.tr/epilepsiData/Uploads/files/14EpilepsiBildiriKongresi.pdf. 

• Talat Taygun Turan, Nursima Mutlu, Merve Açıkel Elmas, Neval Sevinç Özdemir, Nihan Çarçak Yılmaz, Zoltán Molnár, Filiz Onat. "The Role of the Thalamic Orexinergic System in Absence Epilepsy." 16-19 May 2024, 14th National Epilepsy Congress, Muğla, Türkiye. turkepilepsi.org.tr/epilepsiData/Uploads/files/14EpilepsiBildiriKongresi.pdf.

• Devrim Öz Arslan, Nursima Mutlu, Özge Sarıyıldız, Musa Çelik, Zoltán Molnár, Nihan Çarçak Yılmaz, Filiz Onat. "Orexin-2 Receptor Protein Levels in the Thalamocortical Axis in Genetic Absence Epilepsy Rats from Strasbourg." 25-29 June 2024, FENS Forum 2024, Vienna, Austria. fens2024.abstractserver.com/program/#/details/presentations/3575.

• Dilek Akakın, Merve Açıkel Elmas, Ayça Karagöz Köroğlu, Özlem Bingöl Özakpınar, Filiz Onat, Feriha Ercan. "The Effects of Swimming Training on High-Fat Diet-Induced Brain Damage in Rats." 25-30 August 2024, EMC 2024, Copenhagen, Denmark. doi.org/10.1051/bioconf/202412917026.

• Talat Taygun Turan, Filiz Onat. "Brain and Plasma Alpha-Synuclein Levels of Snca flox and Drd1a-Cre Transgenic Mouse Strains." 3-6 September 2024, 22nd National Neuroscience Congress, Istanbul, Türkiye. bad.org.tr/documents/usk_22_2024_ozetler.pdf.

• Aylin Toplu, Nihan Çarçak Yılmaz, Rezzan Gülhan, Filiz Onat. "Impact of Orexin-B Injection into the Intracerebroventricular Region on Absence Epilepsy Seizures." 3-6 September 2024, 22nd National Neuroscience Congress, Istanbul, Türkiye. bad.org.tr/documents/usk_22_2024_ozetler.pdf.

• Filiz Onat, Nursima Mutlu, Merve Açıkel Elmas, Neval Sevinç Özdemir, Nihan Çarçak Yılmaz, Zoltan Molnar. "Orexin Type-2 Receptor Distribution in Genetic Absence Epileptic Rats from Strasbourg." 7-11 September 2024, 15th European Epilepsy Congress, Rome, Italy. doi.org/10.1111/epi.18151.

• Aylin Toplu, Nihan Çarçak Yılmaz, Filiz Onat. "Intracerebroventricular Orexin-B Injection Effect on Absence Epilepsy Seizures." 7-11 September 2024, 15th European Epilepsy Congress, Rome, Italy. doi.org/10.1111/epi.18151.

• Filiz Onat, Talat Taygun Turan, Merve Çavuş, Nursima Mutlu. "Investigation of Alpha-Synuclein Levels in an Animal Model of Absence Epilepsy." 8-11 April 2025, Synuclein Meeting 2025, Cambridge, UK. airdrive.eventsair.com/eventsairwesteuprod/production-openingdoors-public/aa9d7f1f05e84c1eb8a77011002e805a.

• Filiz Onat, Nursima Mutlu, Talat Taygun Turan, Merve Çavuş, Nihan Çarçak Yılmaz. "Orexin Type-1 Receptor Expression in Somatosensory Cortex in Post-natal 21-day-old Rats with Absence Epilepsy." 8-12 July 2025, 16th European Paediatric Neurology Society Congress, Munich, Germany. epns.info/wp-content/uploads/2025/10/EPNS25_Abstractbook.pdf.

• Nihan Çarçak Yılmaz, Merve Çavuş, Nursima Mutlu, Elif Tuğçe Erdeve, Özge Sarıyıldız, Filiz Onat. "Chemogenetic Inhibition of Ventrobasal Thalamus Exacerbates Absence Seizures in Genetic Absence Epilepsy Rat Model." 30 August-3 September 2025, 36th International Epilepsy Congress, Lisbon, Portugal. ilae.org/index.cfm?objectid=03C218D6-D3CD-48E4-04C81CA98374D19D.

• Merve Çavuş, Nursima Mutlu, Nihan Çarçak Yılmaz, Filiz Onat. "A Research About Orexin Type-2 Receptor Protein Expression in Thalamus and Somatosensory Cortex Brain Regions in Rats with Absence Epilepsy." 30 August-3 September 2025, 36th International Epilepsy Congress, Lisbon, Portugal. ilae.org/index.cfm?objectid=03C218D6-D3CD-48E4-04C81CA98374D19D.

• Nursima Mutlu, Talat Taygun Turan, Merve Çavuş, Merve Açıkel Elmas, Neval Sevinç Özdemir, Nihan Çarçak Yılmaz, Filiz Onat. "Orexin Receptor Type-2 Distribution in Prepubertal Neurodevelopmental Stages in Genetic Absence Epileptic Rats from Strasbourg." 30 August-3 September 2025, 36th International Epilepsy Congress, Lisbon, Portugal. ilae.org/index.cfm?objectid=03C218D6-D3CD-48E4-04C81CA98374D19D.

• Elif Tuğçe Erdeve, Filiz Onat, Åda Petersén, Nihan Çarçak Yılmaz, My Andersson. "Involvement of the Orexinergic System in Absence Epilepsy: Developmental Dynamics of Orexin-A." 30 August-3 September 2025, 36th International Epilepsy Congress, Lisbon, Portugal. ilae.org/index.cfm?objectid=03C218D6-D3CD-48E4-04C81CA98374D19D.

• Aylin Toplu, Nihan Çarçak Yılmaz, Rezzan Gülhan, Filiz Onat. "Impact of Intracerebroventricular Orexin-B on Absence Seizures in GAERS: DoseDependent Suppression of Spike-and-Wave Discharges." 30 August-3 September 2025, 36th International Epilepsy Congress, Lisbon, Portugal. ilae.org/index.cfm?objectid=03C218D6-D3CD-48E4-04C81CA98374D19D.

• Oğuzhan Altınkoz, Cem Öztürk, Filiz Onat. "Making It Work: GEMSTONE Project’s Better Practices for Horizon Europe Newcomers." 11-12 September 2025, Building Bridges Conference, Dresden, Germany. building-bridges-conference.eu/#_program.

• GEMSTONE Newsletter 2022-2023

• GEMSTONE Newsletter 2024