WP2 - Research on genetically engineered models
The Work Package 2 of the GEMSTONE Project aims to study genetically engineered models (GEMs) to better understand neurodevelopment and chemogenetic modulation of cortical layer 6b in absence epilepsy, and examine the distribution of α-synuclein expression in different brain regions in a conditional SNCA transgenic mouse model. The research will include ethical approval for animal experiments, chemogenetic modulation, monitoring neurodevelopment, characterizing neuropeptide receptor expression, generating a double transgenic SNCA mouse model, and data analysis.
Acibadem Mehmet Ali Aydinlar University (ACU) and Lund University (ULUND) play key roles in this research. ACU is responsible for ethical approval, monitoring neurodevelopment, characterizing neuropeptide receptors, and analyzing data while ULUND is responsible for chemogenetic modulation, generating the double transgenic model, verifying SNCA deletion, and participating in data analysis. The collaboration between ACU and ULUND will ensure a comprehensive study of GEMs and their impact on neurodevelopment and alpha-synuclein expression.
Updates
WP3 - Transfer of research knowledge and capacity
The objective of the Work Package 3 in the GEMSTONE Project is to address the lack of in-house production of genetically engineered animal models at Acibadem Mehmet Ali Aydinlar University (ACU) by transferring knowledge and skills from Lund University (ULUND). This will be achieved through the transfer of Drd1a Cre and Snap25fl/fl mouse colonies, short-term visits for specialized training, and internal workshops and interactive courses.
ACU will lead the transgenic colony transfer and the internal events and workshops, while ULUND will participate in the short-term visits and the transfer of knowledge and techniques such as chemogenetics and ex-vivo electrophysiology. The goal is to provide ACU researchers with top-level research approaches, technologies, and knowledge to enhance their skills in genetically engineered animal models.
Updates
- Short visit of My Andersson from Lund University to Acibadem University
- GEMSTONE Coordinator gains valuable insights during short visit to ULUND
- Dr. Carcak Yilmaz transfers knowledge in experimental techniques during successful visit to ULUND
- Successful visits to ULUND by GEMSTONE researchers and ACU laboratory animal center
- GEMSTONE course on chemogenetic modulation and validation
- GEMSTONE hosts chemogenetic course at ACU
- Upcoming seminar: Gene regulatory approaches for retinal gene therapies by Dr. Cavit Agca
- Dr. Ozkan Ozdemir's scientific knowledge transfer meeting held at ACU
- GEMSTONE hosts seminar on gene regulatory approaches for retinal gene therapies by Dr. Agca
- Hands-on workshop to unravel neuronal network functionality with advanced recording systems
- GEMSTONE hosts ground-breaking MEA Workshop to advance neuronal network research
- Upcoming seminar: Exploring the effects of alpha-synuclein and amyloid beta on human astrocytes with Dr. Busra Sengul Yediel
- GEMSTONE young researcher Nursima Mutlu advances neurodevelopmental studies in Lund
- GEMSTONE seminar highlights cutting-edge research on astrocytes in neurodegenerative diseases
- Upcoming workshop to explore genetically engineered mouse models and IVF applications
- GEMSTONE Project hosts capacity-building workshop on genetically engineered mouse models and IVF techniques
- GEMSTONE young researchers visit ULUND for advanced training in neurobiology techniques
- GEMSTONE researchers establish IVF technology infrastructure for transgenic mice breeding at ACU